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667-27-6 - Ethyl bromodifluoroacetate, 97% - Bromodifluoroacetic acid ethyl ester - B20461 - Alfa Aesar

B20461 Ethyl bromodifluoroacetate, 97%

CAS-Nummer
667-27-6
Synonyme
Bromodifluoroacetic acid ethyl ester

Größe Preis ($) Menge Verfügbarkeit
1g 19,90
5g 61,80
25g 221,00
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Ethyl bromodifluoroacetate, 97%

MDL
MFCD00042069
EINECS
211-567-0

Chemische Eigenschaften

Formel
BrCF2CO2CH2CH3
Molmasse
202.99
Siedepunkt
112-114°
Flammpunkt
21°(69°F)
Dichte
1.583
Brechungsindex
1.3880
Löslichkeit
Soluble in most organic solvents.

Anwendungen

Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents.

Literaturverweise

S Marcotte.; X Pannecoucke.; C Feasson. Enantioselective Synthesis of α,α-Difluoro-β-amino Acid and 3,3-Difluoroazetidin-2-one via the Reformatsky-Type Reaction of Ethyl Bromodifluoroacetate with Chiral 1,3-Oxazolidines. J. Org. Chem. 199964 ( 23), 8461-8464.

A Sorochinsky.; N Voloshi.; A Markovsky. Convenient Asymmetric Synthesis of β-Substituted α,α-Difluoro-β-amino Acids via Reformatsky Reaction between Davis' N-Sulfinylimines and Ethyl Bromodifluoroacetate. J. Org. Chem. 200368 ( 19), 7448-7454.

Valuable building block for the introduction of the CF2 group by Reformatsky reaction with aldehydes. A further development of this chemistry involves the generation of an ɑɑ-difluoro-ß-lactone, followed by thermal decarboxylation as a high-yield route to 1,1-difluoroalkenes: J. Org. Chem., 60, 5378 (1995):

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H225-H314-H318

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
1906095
Gefahrenklasse
3
Verpackungsgruppe
II
Harmonized Tariff Code
2915.90
TSCA
No

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