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17201-43-3 - 4-(Bromomethyl)benzonitrile, 98% - alpha-Bromo-p-tolunitrile - 4-Cyanobenzyl bromide - B20641 - Alfa Aesar

B20641 4-(Bromomethyl)benzonitrile, 98%

CAS-Nummer
17201-43-3
Synonyme
alpha-Bromo-p-tolunitrile
4-Cyanobenzyl bromide

Größe Preis ($) Menge Verfügbarkeit
5g 45,70
25g 169,00
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4-(Bromomethyl)benzonitrile, 98%

MDL
MFCD00001829
EINECS
241-246-0

Chemische Eigenschaften

Formel
C8H6BrN
Molmasse
196.05
Schmelzpunkt
113-117°
Löslichkeit
Soluble in chloroform and methanol. Insoluble in water.

Anwendungen

4-(Bromomethyl)benzonitrile is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.

Bemerkungen

Moisture and light sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents, strong acids and bases.

Literaturverweise

Alcohols can be protected as their 4-cyanobenzyl ethers, e.g. in the presence of NaH. They can be selectively cleaved by electrolytic reduction: Tetrahrdon Lett., 2643 (1979); Chem. Ber., 114, 946 (1981).

Snelling, R.; Saavedra, J. Z.; Bayrasy, P.; Abdollahian, Y.; Singaram, B. Binary reducing agents containing dichloroindium hydride for the selective, partial, or tandem reductions of bifunctional compounds consisting of halo-nitriles, halo-esters and halo-carboxylic acids. Org. Chem. Front. 2015, 2 (2), 133-140.

Bagala, D. B.; Bhanagea, B. M. Recent Advances in Transition Metal-Catalyzed Hydrogenation of Nitriles. Adv. Synth. Catal. 2015, 357 (5), 883-900.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H311-H331-H317-H314-H318

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. May cause an allergic skin reaction. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P261-P280-P301+P310-P303+P361+P353-P305+P351+P338-P361-P301+P330+P331-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
636717
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2926.90
TSCA
Yes

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