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154-42-7 - 6-Thioguanine, 98% - 2-Amino-6-mercaptopurine - 2-Amino-6-purinethiol - B21280 - Alfa Aesar

B21280 6-Thioguanine, 98%

CAS-Nummer
154-42-7
Synonyme
2-Amino-6-mercaptopurine
2-Amino-6-purinethiol

Größe Preis ($) Menge Verfügbarkeit
1g 62,00
5g 257,00
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6-Thioguanine, 98%

MDL
MFCD00233553
EINECS
205-827-2

Chemische Eigenschaften

Formel
C5H5N5S
Molmasse
167.19
Schmelzpunkt
>360°
Löslichkeit
Soluble in dilute solutions of alkali hydroxides and hot alcohol. Insoluble in water.

Anwendungen

6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerative colitis and autoimmune diseases.

Bemerkungen

Incompatible with strong oxidizing agents.

Literaturverweise

LaDuke, K. E.; Ehling, S.; Cullen, J. M.; Bäumer, W.; Habil, M. V. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am. J. Vet. Res. 2015, 76 (7), 649-655.

Li, P.; Gu, H.; Zhang, J. Characterization of the Interaction of 6-Thioguanine with Human Serum Albumin by Surface-Enhanced Raman Scattering and Molecular Modeling. Anal. Lett. 2015, 48 (13), 2063-2074.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301

Toxic if swallowed.

Sicherheitshinweise: P264-P270-P301+P310a-P321-P405-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Specific treatment (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9337
Beilstein
157765
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2933.59
TSCA
No
RTECS
UP0740000

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