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54-71-7 - (+)-Pilocarpine hydrochloride, 99% - B21410 - Alfa Aesar

B21410 (+)-Pilocarpine hydrochloride, 99%

CAS-Nummer
54-71-7
Synonyme

(+)-Pilocarpine hydrochloride, 99%

MDL
MFCD00012722
EINECS
200-212-5

Chemische Eigenschaften

Formel
C11H16N2O2•HCl
Molmasse
244.72
Schmelzpunkt
202-205°
Sensitivität
Hygroscopic
Löslichkeit
Soluble in water (100 mg/ml, with heat as needed), alcohol, chloroform (slightly), DMSO (75 mM), and ethanol. Insoluble in ether.

Anwendungen

(+)-Pilocarpine hydrochloride is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses. (+)-Pilocarpine hydrochloride is a nonselective AChR (cholinergic) agonist that acts under high junctional concentrations of the neurotransmitter. Also, a parasympathomimetic agent with the muscarinic effects of acetylcholine. (+)-Pilocarpine hydrochloride is an activator of mAChR M.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Stable under recommended storage conditions. Keep away from strong oxidizing agents. Hygroscopic. Store at 4°C.

Literaturverweise

S Miyazaki.; S Suzuki.; N Kawasaki.; K Endo. In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. International Journal of Pharmaceutics. 2001229 (1-2), 29-36.

RM Nagler.; A Nagler. Pilocarpine hydrochloride relieves xerostomia in chronic graft-versus-host disease: a sialometrical study. Bone marrow transplantation. 199923 (10), 1007-1011.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H330

Fatal if swallowed. Fatal if inhaled.

Sicherheitshinweise: P260-P284-P301+P310-P304+P340-P320-P330-P310-P405-P403+P233-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,7424
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2939.99
TSCA
Yes
RTECS
TK1450000

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