Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

10238-21-8 - Glybenzcyclamide, 99% - Glibenclamide - Glyburide - B21459 - Alfa Aesar

B21459 Glybenzcyclamide, 99%

CAS-Nummer
10238-21-8
Synonyme
Glibenclamide
Glyburide

Größe Preis ($) Menge Verfügbarkeit
25g 77,20
100g 284,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Glybenzcyclamide, 99%

MDL
MFCD00056625
EINECS
233-570-6

Chemische Eigenschaften

Formel
C23H28ClN3O5S
Molmasse
494.01
Schmelzpunkt
171-174°
Löslichkeit
Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

Anwendungen

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 ?M).

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Literaturverweise

DG Dills.; J Schneider. Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Glimepiride/Glyburide Research Group. Hormone and metabolic research= Hormone. 199628 (9), 426-429.

M Jab?rek.; V Yarov-Yarovoy.; P Paucek. State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate. Hormone and metabolic research= Hormone. 1998273 (9), 13578-13582.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H303

May be harmful if swallowed.

Sicherheitshinweise: P312a

Call a POISON CENTER/doctor if you feel unwell.

Weitere Referenzen

Harmonized Tariff Code
2935.90
TSCA
No

Empfohlen

  • A10459

    Quinine, anhydrous, 99% (total base), may cont. up to 5% dihydroquinine
  • A10772

    Triethylene glycol, 99%
  • A11165

    Hemin (porcine), 97+%
  • A12559

    (+)-Quinidine
  • A12747

    1,1,1,3,3,3-Hexafluoro-2-propanol, 99+%

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf