B21481 4-Chloro-2-(methylthio)pyrimidine, 98%
SDS
| Stock No. | Größe | Preis ($) | Menge | Verfügbarkeit |
|---|---|---|---|---|
| B21481-09 | 10g | 60,60 |
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| B21481-18 | 50g | 247,00 |
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| B21481-30 | 250g | 1110,00 |
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4-Chloro-2-(methylthio)pyrimidine, 98%
Chemische Eigenschaften
Anwendungen
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.
Bemerkungen
Literaturverweise
Daves GD, et al. Pyrimidines. XIII. 2-and 6-substituted 4-pyrimidinecarboxylic acids.J. Heterocycl. Chem.19641(3), 130-133.
Peter J Manley, et al. 2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.Bioorg. Med. Chem. Lett.200313(10), 1673-1677.
GHS Gefahren- und Sicherheitshinweise
Gefahrenhinweise (EU): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Sicherheitshinweise: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
