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49844-90-8 - 4-Chloro-2-(methylthio)pyrimidine, 98% - 4-Chloro-2-(methylmercapto)pyrimidine - B21481 - Alfa Aesar

B21481 4-Chloro-2-(methylthio)pyrimidine, 98%

CAS-Nummer
49844-90-8
Synonyme
4-Chloro-2-(methylmercapto)pyrimidine

Größe Preis ($) Menge Verfügbarkeit
10g 61,80
50g 252,00
250g 1133,00
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4-Chloro-2-(methylthio)pyrimidine, 98%

MDL
MFCD00006083
EINECS
256-500-6

Chemische Eigenschaften

Formel
C5H5ClN2S
Molmasse
160.63
Schmelzpunkt
ca -2°
Siedepunkt
118-120°/9mm
Flammpunkt
>110°(230°F)
Dichte
1.380
Brechungsindex
1.6 00
Sensitivität
Moisture Sensitive
Löslichkeit
Not miscible or difficult to mix in water.

Anwendungen

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Bemerkungen

Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.

Literaturverweise

Daves GD, et al. Pyrimidines. XIII. 2-and 6-substituted 4-pyrimidinecarboxylic acids.J. Heterocycl. Chem.19641(3), 130-133.

Peter J Manley, et al. 2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.Bioorg. Med. Chem. Lett.200313(10), 1673-1677.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P304+P312a

IF INHALED:

Weitere Referenzen

Beilstein
118042
Gefahrenklasse
8
Verpackungsgruppe
III
Harmonized Tariff Code
2933.59
TSCA
No

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