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1694-92-4 - 2-Nitrobenzenesulfonyl chloride, 97% - B21522 - Alfa Aesar

B21522 2-Nitrobenzenesulfonyl chloride, 97%

CAS-Nummer
1694-92-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
25g 33,75
100g 95,46
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2-Nitrobenzenesulfonyl chloride, 97%

MDL
MFCD00007430
EINECS
216-907-1

Chemische Eigenschaften

Formel
C6H4ClNO4S
Molmasse
221.62
Schmelzpunkt
64-69°
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in toluene, tetrahydrofuran, methylene chloride, ethyl acetate and dimethylformamide. Insoluble in water.

Anwendungen

2-Nitrobenzenesulfonyl chloride acts as a reagent to form 2-nitrobenzenesulfonyl derivatives of alcohols and amines. It is also involved in the selective cleavage with thiophenol without displacement of the nitro group. Further, it is used in the preparation of renin inhibitors. In addition to this, it finds application as an anticonvulsant.

Bemerkungen

Moisture sensitive. Incompatible with strong oxidizing agents and strong bases.

Literaturverweise

Reagent for formation of 2-nitrobenzenesulfonyl derivatives of alcohols and amines, e.g. in the presence of triethylamine. Selective cleavage with PhSH occurs without displacement of the nitro group which sometimes occurs with the 4-nitro isomer (see following entry): Tetrahedron Lett., 36, 6373 (1995). See also 2-Nitrobenzenesulfonamide, A15689.

Hfaiedh, A.; Yuan, K.; Ammar, H. B.; Hassine, B. B.; Soulé, J. F.; Doucet, H. Eco-Friendly Solvents for Palladium-Catalyzed Desulfitative C-H Bond Arylation of Heteroarenes. ChemSusChem 2015, 8 (10), 1794-1804.

Takanashi, N.; Suzuki, K.; Kitajima, M.; Takayama, H. Total synthesis of conolidine and apparicine. Tetrahedron Lett. 2016, 57 (3), 375-378.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
521155
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2904.90
TSCA
Yes

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