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64-77-7 - Tolbutamide, 98% - 1-n-Butyl-3-(p-tolylsulfonyl)urea - B21698 - Alfa Aesar

B21698 Tolbutamide, 98%

CAS-Nummer
64-77-7
Synonyme
1-n-Butyl-3-(p-tolylsulfonyl)urea

Größe Preis ($) Menge Verfügbarkeit
10g 45,90
50g 153,00
250g 543,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Tolbutamide, 98%

MDL
MFCD00027169
EINECS
200-594-3

Chemische Eigenschaften

Formel
C12H18N2O3S
Molmasse
270.35
Schmelzpunkt
128-130°
Löslichkeit
Soluble in chloroform.

Anwendungen

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

Sullivan-Klose,et.al. The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics. 1996, 6 (4), 2702-2705.

Michael Perley, MD; and David M Kipnis, MD. Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects. Diabetes, 1966, 15(12), 867-874.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H317

Harmful if swallowed. May cause an allergic skin reaction.

Sicherheitshinweise: P261-P280-P264-P270-P301+P312-P363-P321-P333+P313-P302+P352-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. IF ON SKIN: Wash with plenty of soap and water. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9507
Beilstein
1984428
Harmonized Tariff Code
2935.00
TSCA
Yes
RTECS
YS4550000

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