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2-(Phenoxymethyl)oxirane is used in the synthesis of hydrazide-containing inhibitors of HIV-1 integrase.
Zhao, H. et al. Hydrazide-Containing Inhibitors of HIV-1 Integrase.J. Med. Chem.199740(6), 937-941.
E Van den Eeckhout; A De Bruyn; H Pepermans; E L Esmans; I Vryens, J Claereboudt; M Claeys; J E Sinsheimer. Adduct formation identification between phenyl glycidyl ether and 2'-deoxyadenosine and thymidine by chromatography, mass spectrometry and nuclear magnetic resonance spectroscopy.Journal of Chromatography A.1991541(1-2), 317-331.
Gefahrenhinweise (EU): H332-H315-H317-H341-H350-H335
Harmful if inhaled. Causes skin irritation. May cause an allergic skin reaction. Suspected of causing genetic defects. May cause cancer. May cause respiratory irritation.
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.