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108549-23-1 - Dibenzyl diisopropylphosphoramidite, 95% - B22629 - Alfa Aesar

B22629 Dibenzyl diisopropylphosphoramidite, 95%

CAS-Nummer
108549-23-1
Synonyme

Größe Preis ($) Menge Verfügbarkeit
5g 84,50
25g 280,00
100g 898,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Dibenzyl diisopropylphosphoramidite, 95%

MDL
MFCD00191988

Chemische Eigenschaften

Formel
C20H28NO2P
Molmasse
345.43
Siedepunkt
130°/0.55mm
Flammpunkt
69°(156°F)
Dichte
1.030
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in chloroform.

Anwendungen

Dibenzyl N,N-diisopropylphosphoramidite may be used for the preparation of phosphopeptides. It is used for the synthesis of a GDP (guanosine diphosphate) analog, SML-8-73-1. It is useful for nucleotide coupling.

Bemerkungen

Moisture sensitive. Store under inert gas. Store at 0°C. Incompatible with oxidizing agents, water/ moisture.

Literaturverweise

D L Clemm; L Sherman; V Boonyaratanakornkit; W T Schrader; N L Weigel; D P Edwards. Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Molecular Endocrinology. 2000, 14 (1), 52-65.

Sang Min Lim; Kenneth D Westover; Scott B Ficarro; Rane A Harrison; Hwan Geun Choi; Michael E Pacold; Martin Carrasco; John Hunter; Nam Doo Kim; Ting Xie; Taebo Sim, Pasi A Jänne; Matthew Meyerson; Jarrod A Marto; John R Engen; Nathanael S Gray. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angewandte Chemie. 2014, 53 (1), 199-204.

Phosphitylating agent which reacts with an alcohol under mild conditions. Subsequent oxidation, e.g. with hydrogen peroxide, followed by hydrogenolysis of the benzyl groups, affords the alkyl phosphate: Tetrahedron Lett., 29, 979 (1988).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P210u-P261-P280a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2929.90
TSCA
No

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