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1538-75-6 - Trimethylacetic anhydride, 99% - Pivalic anhydride - B22983 - Alfa Aesar

B22983 Trimethylacetic anhydride, 99%

CAS-Nummer
1538-75-6
Synonyme
Pivalic anhydride

Größe Preis ($) Menge Verfügbarkeit
25g 45,00
100g 130,00
500g 593,00
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Trimethylacetic anhydride, 99%

MDL
MFCD00008842
EINECS
216-263-1

Chemische Eigenschaften

Formel
C10H18O3
Molmasse
186.25
Siedepunkt
193°
Flammpunkt
63°(145°F)
Dichte
0.918
Brechungsindex
1.4090
Sensitivität
Moisture Sensitive
Löslichkeit
Miscible with acetonitrile.

Anwendungen

Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

Bemerkungen

Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.

Literaturverweise

The direct hydrogenation of carboxylic acids to aldehydes has been achieved in the presence of pivalic anhydride and Tetrakis(triphenyl­phosphine)­palladium(0)­, 10548 : Chem. Lett., 1143 (1998).

Alcohols can be protected as their pivaloyl (Pv) esters by reaction with the anhydride in the presence of MgBr2 - Et3N or Sc(OTf)3 in acetonitrile: J. Org. Chem., 61, 5702 (1996). See also Trimethyl­acetyl­ chloride, A15051 .

Zhu, J. L.; Liu, Y.; Liu, X. Y.; Liu, H. J.; Chen, Y. Multi stimuli-responsive photoluminescent nanocomposite of silver nanoclusters with hyperbranched polyethylenimine derivatives. RSC Adv. 2015, 5 (11), 8146-8151.

Wu, J.; Leng, W. L.; Liao, H.; Hoang, K. L. M.; Le, K.; Liu, X. W. Intramolecular C-N Bond Formation under Metal-free Conditions: Synthesis of Indolizines. Chem. Asian J. 2015, 10 (4), 853-856.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H227-H314-H318

Combustible liquid. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
386552
Gefahrenklasse
8
Verpackungsgruppe
III
Harmonized Tariff Code
2915.90
TSCA
Yes

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