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p-Tolyl chlorothionoformate is used in dehydration reactions by cyclic elimination of thiocarbonate esters. It acts as a catalyst in the synthesis of alfa-L-2'-deoxythreofuranosyl nucleoside analogs and alkenes from hindered alcohols.
For examples of the use of aryl chlorothionoformates in dehydration reactions by cyclic elimination of thiocarbonate esters, see Phenyl chlorothionoformate, L00838.
Toti, K. S.; Derudas, M.; McGuigan, C.; Balzarini, J.; Van Calenbergh, S. Synthesis and antiviral evaluation of alpha-l-2'-deoxythreofuranosyl nucleosides. Eur. J. Med. Chem. 2011, 46 (9), 3704-3713.
Varaprasad, C. V.; Ramasamy, K. S.; Hong, Z. Synthesis of some monocyclic-N-acetyl 4'-aza-D-nucleosides. J. Heterocycl. Chem. 2006, 43 (2), 325-336.
Gefahrenhinweise (EU): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.