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103-74-2 - 2-(2-Hydroxyethyl)pyridine, 99% - 2-Pyridineethanol - 2-(2-Pyridyl)ethanol - B23579 - Alfa Aesar

B23579 2-(2-Hydroxyethyl)pyridine, 99%

CAS-Nummer
103-74-2
Synonyme
2-Pyridineethanol
2-(2-Pyridyl)ethanol

Größe Preis ($) Menge Verfügbarkeit
100g 27,20
500g 85,20
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2-(2-Hydroxyethyl)pyridine, 99%

MDL
MFCD00006364
EINECS
203-140-2

Chemische Eigenschaften

Formel
C7H9NO
Molmasse
123.16
Schmelzpunkt
-8°
Siedepunkt
235-238°
Flammpunkt
117°(243°F)
Dichte
1.095
Brechungsindex
1.5370
Sensitivität
Hygroscopic
Löslichkeit
Soluble in Chloroform (Slightly), Methanol (Slightly).

Anwendungen

2-(2-Hydroxyethyl)pyridine is a metabolite of the anti-vertigo drug Betahistine. It acts as a reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. It is used for carboxyl protection of amino acids. It is also used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. It was used to prepare mononuclear nickel(II) acetate.

Bemerkungen

Hygroscopic. Store under dry inert gas. Store away from moisture, strong bases and oxidizing agents. Protect from humidity and water.

Literaturverweise

Miha Trdin; Valter Bergant; Ivan Leban; Nina Lah. Two concomitant polymorphs of monomeric nickel acetate with 2-pyridineethanol. Acta Chimica Slovenica. 2012, 59, (3), 478-483.

Takashi Niwa; Hideki Yorimitsu; Koichiro Oshima. Palladium-Catalyzed 2-Pyridylmethyl Transfer from 2-(2-Pyridyl)ethanol Derivatives to Organic Halides by Chelation-Assisted Cleavage of Unstrained Cmath image[BOND]Cmath image Bonds. Angewandte Chemie (International Edition). 2007, 46, (15), 2643-2645.

Reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. The group can be introduced by DCC-coupling, is stable to mild base, but can be cleaved by methoxide in pyridine-methanol: Chem. Ber., 103, 1032 (1970).

Has also been used for carboxyl protection of amino acids. Pet esters are stable to both mildly acidic and basic conditions used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. Cleavage is by quaternization with methyl iodide in the presence of mild base: Tetrahedron Lett., 25, 3971 (1984); Angew. Chem. Int. Ed., 23, 716 (1984). See Appendix 6.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Sicherheitshinweise: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
111205
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
UT2970450

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