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Pyruvic aldehyde dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.
K Ispolnov; R A Gomes; M S Silva; A P Freire. Extracellular methylglyoxal toxicity in Saccharomyces cerevisiae: role of glucose and phosphate ions. Proceedings of the Society of Agricultural Bacteriologists.2008, 104, (4), 1092-1102.
Ricardo A Gomes; Marta Sousa Silva; Hugo Vicente Miranda; António E N Ferreira; Carlos A A Cordeiro; Ana Ponces Freire. Protein glycation in Saccharomyces cerevisiae. Argpyrimidine formation and methylglyoxal catabolism. FEBS Journal.2005, 272, (17), 4521-4531.
The cyclohexylimine or the N,N-dimethylhydrazone can be lithiated at the methyl group with LDA to give useful synthetic species capable of alkylation, etc.: Synthesis, 198 (1977). For a review of the alkylation of nitrogen derivatives of carbonyl compounds, see: Synthesis, 517 (1983).
Gefahrenhinweise (EU): H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.