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2-Fluoro-4-methylbenzonitrile is used in the synthesis of fluorobenzamidrazone thrombin inhibitors.
Liping H. Pettus,; Shimin Xu,; Guo-Qiang Cao,; Partha P. Chakrabart,; Robert M. Rzasa,; Kelvin Sham,; Ryan P. Wurz,; Dawei Zhang,; Scott Middleton,; Bradley Henkle,; Matthew H. Plant,; Christiaan J. M. Saris,; Lisa Sherman,; Lu Min Wong,; David A. Powers,; Yanyan Tudor,; Violeta Yu,; Matthew R. Lee,; Rashid Syed,; Faye Hsieh,; Andrew S. Tasker.3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase. J. Med. Chem. 2008, 51 (20),6280-6292.
Gefahrenhinweise (EU): H302-H312-H331-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.