I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
Lawson, W.B., et al,; Folia Haematol. Int. Mag. Klin. Studies on the inhibition of human thrombin: effects of plasma and plasma constituents. Morphol. Blutforsch. 1982, 109(52)
M Citron,; T.S Diehl,; A Capell,; C Haass,; D.B Teplow,; D.J Selkoe. Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF. Journal name. 1996, 17 (1),171-179.
Irreverersible serine protease inhibitor: Thromb. Res., 2, 343 (1973); Acta Biol. Med. Ger., 39, 355 (1980).
Gefahrenhinweise (EU): H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Obtain special instructions before use. Wear eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.