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30827-99-7 - 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97% - AEBSF - H26473 - Alfa Aesar

H26473 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

CAS-Nummer
30827-99-7
Synonyme
AEBSF

Größe Preis ($) Menge Verfügbarkeit
250mg 198,00
1g 529,60
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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

MDL
MFCD00132962

Chemische Eigenschaften

Formel
C8H10FNO2S•HCl
Molmasse
239.69
Schmelzpunkt
ca 184° dec.
Sensitivität
Moisture Sensitive
Löslichkeit
Soluble in water 50 mg/mL or 100% ethanol.

Anwendungen

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Bemerkungen

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.

Literaturverweise

Lawson, W.B., et al,; Folia Haematol. Int. Mag. Klin. Studies on the inhibition of human thrombin: effects of plasma and plasma constituents. Morphol. Blutforsch. 1982, 109(52)

M Citron,; T.S Diehl,; A Capell,; C Haass,; D.B Teplow,; D.J Selkoe. Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF. Journal name. 1996, 17 (1),171-179.

Irreverersible serine protease inhibitor: Thromb. Res., 2, 343 (1973); Acta Biol. Med. Ger., 39, 355 (1980).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
7604627
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2922.29
TSCA
No

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