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The largest gain in affinity of all tested unnatural amino acids was observed for 2-chloro-L-phenylalanine.
Robert Opitza,; Matthias Müllera,; Cédric Reuterb,; Matthias Baronea,; Arne Soickeb,; Yvette Roskec,; Kirill Piotukh. A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions. Journal name. 2015, 112(16) ,5011-5016.