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5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.
Chen Li,; Avrum I. Gotlieb. Transforming Growth Factor-β Regulates the Growth of Valve Interstitial Cellsin Vitro. The American Journal of Pathology. 2011, 179 (4), 1746-1755 .
Yu Gui et. al. Signaling mechanisms mediating uridine adenosine tetraphosphate-induced proliferation of human vascular smooth muscle cells. Journal of Cardiovascular Pharmacology. 2011 , 58(6), 654-662 .
Thymidine analog, preferentially incorporated into cellular DNA in place of thymidine, producing increased radiosensitivity of the cell: Int. J. Radiat. Oncol. Biol. Phys., 10, 1399 (1984); 21, 709 (1991). Mutagen used in genetic research: Mutat. Res., 258, 161 (1991). Reviews on use in diagnostics and research: Histochem. J., 27, 339, 923 (1995; 28, 531 (1996).
Gefahrenhinweise (EU): H341
Suspected of causing genetic defects.
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