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117924-33-1 - Di-tert-butyl N,N-diethylphosphoramidite, 94% - H27380 - Alfa Aesar

H27380 Di-tert-butyl N,N-diethylphosphoramidite, 94%

CAS-Nummer
117924-33-1
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 63,70
5g 196,00
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Di-tert-butyl N,N-diethylphosphoramidite, 94%

MDL
MFCD00134307

Chemische Eigenschaften

Formel
[(CH3)3CO]2PN(CH2CH3)2
Molmasse
249.33
Siedepunkt
39-41°/0.3mm
Flammpunkt
78°(172°F)
Dichte
0.896
Brechungsindex
1.434
Sensitivität
Moisture Sensitive
Löslichkeit
Hydrolyzes in water. Soluble in chloroform and methanol.

Anwendungen

A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

Bemerkungen

Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.

Literaturverweise

Perich. J. W, et al. Di-tert-butyl N,N-diethylphosphoramidite. A new phosphitylating agent for the efficient phosphorylation of alcohols.Synthesis.,1988,2142-144.

Roland Sauer, et al. Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists.J. Med. Chem.,2000,43(3), 440-448.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H227-H315-H319

Combustible liquid. Causes skin irritation. Causes serious eye irritation.

Sicherheitshinweise: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Weitere Referenzen

Harmonized Tariff Code
2931.39
TSCA
No

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