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90347-66-3 - Methyl 3-iodo-4-methylbenzoate, 98% - 3-Iodo-4-methylbenzoic acid methyl ester - H28734 - Alfa Aesar

H28734 Methyl 3-iodo-4-methylbenzoate, 98%

CAS-Nummer
90347-66-3
Synonyme
3-Iodo-4-methylbenzoic acid methyl ester

Größe Preis ($) Menge Verfügbarkeit
5g 52,90
25g 154,00
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Methyl 3-iodo-4-methylbenzoate, 98%

MDL
MFCD00230583

Chemische Eigenschaften

Formel
C9H9IO2
Molmasse
276.07
Brechungsindex
1.5975
Sensitivität
Light Sensitive
Löslichkeit
Not miscible or difficult to mix with water.

Anwendungen

Methyl 3-Iodo-4-methylbenzoate is used as a reagent in the synthesis of [(pyrazolo[1,5-a]pyridmidinyl)ethynyl]benzamides as selective discoidin domain receptor 1 (DDR1) inhibitors. Also used as a reagent in the preparation of orally bioavailable GZD824 targeting Breakpoint Cluster Region-Abelson (Bcr-Abl) kinase and overcoming antitumor drug resistance.

Bemerkungen

Light Sensitive, store in dark. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

Gao, M., et al. Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem. 2013, 56(8), 3281-3295.

Ren, X., et al. Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib.J. Med. Chem. 2013, 56(3), 879-894.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319

Causes skin irritation. Causes serious eye irritation.

Sicherheitshinweise: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2916.39
TSCA
No

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