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87120-72-7 - 4-Amino-1-Boc-piperidine, 97% - 1-Boc-4-piperidinamine - tert-Butyl 4-aminopiperidine-1-carboxylate - H30779 - Alfa Aesar

H30779 4-Amino-1-Boc-piperidine, 97%

CAS-Nummer
87120-72-7
Synonyme
1-Boc-4-piperidinamine
tert-Butyl 4-aminopiperidine-1-carboxylate

Größe Preis ($) Menge Verfügbarkeit
1g 48,64
5g 150,75
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4-Amino-1-Boc-piperidine, 97%

MDL
MFCD01076201

Chemische Eigenschaften

Formel
C10H20N2O2
Molmasse
200.28
Schmelzpunkt
44-48°
Sensitivität
Air Sensitive
Löslichkeit
Insoluble in water.

Anwendungen

4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.

Bemerkungen

Air Sensitive, store away from air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

Calum Macleod; Blanca I Martinez-Teipel; William M Barker; Roland E Dolle. Annulation of primary amines to piperazines and diazaspirocycles utilizing alpha-methyl benzyl resin. Journal of Combinatorial Chemistry,2006, 8(1), 132-140.

Demont, E. et al. Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J. Med. Chem,2015, 58 (14), 5649-5673.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Weitere Referenzen

Gefahrenklasse
8
Verpackungsgruppe
III
Harmonized Tariff Code
2933.39
TSCA
No

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