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Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst.
Abás, S.; Estarellas, C.; Luque, F. J.; Escolano, C. Easy access to (2-imidazolin-4-yl)phosphonates by a microwave assisted multicomponent reaction. Tetrahedron 2015, 71 (19), 2872-2881.
de la Campa, R.; Ortín, I.; Dixon, D. J. Direct Catalytic Enantio- and Diastereoselective Ketone Aldol Reactions of Isocyanoacetates. Angew. Chem. Int. Ed. 2015, 127 (16), 4977-4980.
Gefahrenhinweise (EU): H227-H302-H312-H331-H314-H318
Combustible liquid. Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.