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In discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors 2-Fluoro-5-(trifluoromethoxy)aniline is used as coupling agent. 2-Fluoro-5-(trifluoromethyl)aniline may be used in chemical synthesis studies.
Masaki Setoh,; Naoki Ishii,; Mitsunori Kono,; Yuhei Miyanohana,; Eri Shiraish,; Toshiya Harasawa,; Hiroyuki Ota,; Tomoyuki Odani,; Naoyuki Kanzaki,; Kazunobu Aoyama,; Teruki Hamada,; Masakuni Kori. Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor 52. J. Med. Chem. 2014 , 57(12) ,5226-5237.
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Gefahrenhinweise (EU): H302-H311-H332-H315-H319
Harmful if swallowed. Toxic in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation.
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