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Potassium methoxymethyltrifluoroborate is used in the cross-coupling of mesylated phenol derivatives. The corresponding aryl- and heteroaryl alkoxymethyl compounds are prepared with both electron-rich and electron-poor substituents on the activated alcohol.
OBrien, N. J.; Brzozowski, M.; Wilson, D. J.; Deady, L. W.; Abbott, B. M. Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors. Bioorg. Med. Chem. 2014, 22 (14), 3781-3790.
Molander, G. A.; Beaumard, F. Cross-Coupling of Mesylated Phenol Derivatives with Potassium Alkoxymethyltrifluoroborates. Org. Lett. 2011, 13 (15), 3948-3951.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.