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6-Bromopyrazolo[1,5-a]pyrimidine is a reactant in the synthesis of LDN-212854, a selective and potent inhibitor of the BMP type I receptor kinases.
Agustin H. Mohedas; Xuechao Xing; Kelli A. Armstrong; Alex N. Bullock; Gregory D. Cuny; and Paul B. Yu. Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem. Biol. 20138 (6), 1291-1302
Mingshan Gao; Lei Duan; Jinfeng Luo; Lianwen Zhang; Xiaoyun Lu; Yan Zhang; Zhang Zhang; Zhengchao Tu; Yong Xu; Xiaomei Ren; and Ke Ding. Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem. 201356 (8), 3281-3295
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.