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75330-75-5 - Lovastatin, 97% - Mevacor - H52792 - Alfa Aesar

H52792 Lovastatin, 97%

CAS-Nummer
75330-75-5
Synonyme
Mevacor

Größe Preis ($) Menge Verfügbarkeit
5g 59,60
25g 239,00
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Lovastatin, 97%

MDL
MFCD00072164

Chemische Eigenschaften

Formel
C24H36O5
Molmasse
404.56
Schmelzpunkt
175°
Löslichkeit
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Anwendungen

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Bemerkungen

Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Literaturverweise

Jonathan A.Tobert. Efficacy and long-term adverse effect pattern of lovastatin. The American Journal of Cardiology. 1988, 62, (15),J28-J34

 

Peter Jones MD; Stephanie Kafonek MD; Irene Laurora PharmD; Donald Hunninghake MD. Comparative Dose Efficacy Study of Atorvastatin VersusSimvastatin, Pravastatin, Lovastatin, and Fluvastatin in Patients With Hypercholesterolemia (The CURVES Study). The American Journal of Cardiology. 1998, 81, (5),582-587

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2932.20
TSCA
No
RTECS
EK7907000

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