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4-Aminomethyl-1-Boc-piperidine is used in the preparation biologically active compounds and orally active platelet-activating factor antagonists. It is used as an inhibitor for aspartic acid protease and Kinesin spindle protein. It is an active reactant involved in the enantioselective synthesis of N-alkyl terminal aziridines.
Theoclitou, M. E.; Aquila, B.; Block, M. H.; Brassil, P. J.; Castriotta, L.; Code, E.; Collins, M. P.; Davies, A. M.; Deegan, T.; Ezhuthachan, J.; Filla, S.; Freed, E.; Hu, H.; Huszar, D.; Jayaraman, M.; Lawson, D.; Lewis, P. M.; Nadella, M. V.; Oza, V.; Padmanilayam, M.; Pontz, T.; Ronco, L.; Russell, D.; Whitston, D.; Zheng, X. Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med. Chem. 2011, 54 (19), 6734-6750.
Xiang, Y.; Hirth, B.; Asmussen, G.; Biemann, H. P.; Bishop, K. A.; Good, A.; Fitzgerald, M.; Gladysheva, T.; Jain, A.; Jancsics, K.; Liu, J.; Metz, M.; Papoulis, A.; Skerlj, R.; Stepp, J. D.; Wei, R. R. The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorg. Med. Chem. Lett. 2011, 21 (10), 3050-3056.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.