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76513-69-4 - 2-(Chloromethoxy)ethyltrimethylsilane, tech. 90%, stab. with 0.1% N,N-Diisopropylethylamine - 2-(Trimethylsilyl)ethoxymethyl chloride - SEM-chloride - H55074 - Alfa Aesar

H55074 2-(Chloromethoxy)ethyltrimethylsilane, tech. 90%, stab. with 0.1% N,N-Diisopropylethylamine

CAS-Nummer
76513-69-4
Synonyme
2-(Trimethylsilyl)ethoxymethyl chloride
SEM-chloride

Größe Preis ($) Menge Verfügbarkeit
1g 32,70
5g 118,00
25g 452,00
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2-(Chloromethoxy)ethyltrimethylsilane, tech. 90%, stab. with 0.1% N,N-Diisopropylethylamine

MDL
MFCD00009919
EINECS
278-483-4

Chemische Eigenschaften

Formel
C6H15ClOSi
Molmasse
166.72
Siedepunkt
170-172°
Flammpunkt
46°(115°F)
Dichte
0.942
Brechungsindex
1.4350
Sensitivität
Moisture Sensitive

Anwendungen

2-(Chloromethoxy)ethyltrimethylsilane is used in the preparation of SEM [2-(trimethylsilyl)ethoxy]methyl]-ethers. It serves as a phenol protecting group in the synthesis of laterifluorones. Further, it reacts with 1H-imidazole to prepare 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole.

Bemerkungen

Store in a cool place. Moisture sensitive. Incompatible with strong oxidizing agents.

Literaturverweise

Saito, A.; Higgins, M.; Zheng, S.; Li, W.; Ojima, I.; Dinkova-Kostova, A. T.; Honda, T. Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets. Bioorg. Med. Chem. Lett. 2013, 23 (20), 5540-5543.

Gonzalez, A. Z.; Li, Z.; Beck, H. P.; Canon, J.; Chen, A.; Chow, D.; Duquette, J.; Eksterowicz, J.; Fox, B. M.; Fu, J.; Huang, X.; Houze, J.; Jin, L.; Li, Y.; Ling, Y.; Lo, M. C.; Long, A. M.; McGee, L. R.; McIntosh, J.; Oliner, J. D.; Osgood, T.; Rew, Y.; Saiki, A. Y.; Shaffer, P.; Wortman, S.; Yakowec, P.; Yan, X.; Ye, Q.; Yu, D.; Zhao, X.; Zhou, J.; Olson, S. H.; Sun, D.; Medina, J. C. Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres. J. Med. Chem. 2014, 57 (7), 2963-2988.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H226-H314-H318

Flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.

Sicherheitshinweise: P260u-P201-P280a-P304+P340-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Beilstein
3587289
Gefahrenklasse
8
Verpackungsgruppe
II
Harmonized Tariff Code
2931.90
TSCA
No

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