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It is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Valine is one of the simplest amino acids - an isopropyl group as the side chain. This smaller side chain confers a fairly high degree of flexibility when incorporated into a polypeptide chain. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.
Yanping Chen, et al. Total Synthesis of the Depsipeptide FR-901375.J. Org. Chem.,2003,68(23), 8902-8905.
Khan W. Li, et al. Total Synthesis of the Antitumor Depsipeptide FR-901,228.J. Am. Chem. Soc.,1996,118(30), 7237-7238.