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6-Chloropurine riboside is used to study the kinetics and substrate specificity of adenosine deaminase. 6-Chloropurine riboside is benzoylated to facilitate synthesis of nucleoside derivatives such as 9-(2,3-Di-deoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine. It , especially after phosphorylation to NMP, NDP or NTP, is used as a purine substrate analogue in studies with enzymes such as Inosine monophosphate dehydrogenase (IMPDH); bacteriophage T4 RNA-ligase (EC 188.8.131.52) and pancreatic fibonuclease A.
Juli Alonso.; M.Victòria Nogués.; Claudi M. Cuchillo. Modification of bovine pancreatic ribonuclease A with 6-chloropurine riboside. Arch. Biochem. Biophys. 1986, 246 (2),681-689.
Michal Hocek .; Antonín Holý.; Ivan Votruba.; Hana Dvo?áková. Synthesis and Cytostatic Activity of Substituted 6-Phenylpurine Bases and Nucleosides:? Application of the Suzuki-Miyaura Cross-Coupling Reactions of 6-Chloropurine Derivatives with Phenylboronic Acids.J. Med. Chem. 2000, 43 (9),1817-1825.