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402-61-9 - 3-Methyl-1H-pyrazole-5-carboxylic acid, 97% - H59899 - Alfa Aesar

H59899 3-Methyl-1H-pyrazole-5-carboxylic acid, 97%

CAS-Nummer
402-61-9
Synonyme

Größe Preis ($) Menge Verfügbarkeit
1g 97,70
5g 342,00
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3-Methyl-1H-pyrazole-5-carboxylic acid, 97%

MDL
MFCD00462235

Chemische Eigenschaften

Formel
C5H6N2O2
Molmasse
126.11
Schmelzpunkt
236-240°
Löslichkeit
Soluble in dimethyl sulfoxide.

Anwendungen

3-Methylpyrazole-5-carboxylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carboxylic acid specifically prevents formalin-induced tonic pain.

Bemerkungen

Store at room temperature. Keep away from oxidizing agents.

Literaturverweise

Donald J. P. Pinto.; Michael J. Orwat.; Shuaige Wang.; John M. Fevig.; Mimi L. Quan.; Eugene Amparo.; Joseph Cacciola.; Karen A. Rossi.; Richard S. Alexander.; Angela M. Smallwood.; Joseph M. Luettgen.; Li Liang.; Bruce J. Aungst.; Matthew R. Wright.; Robert M. Knabb.; Pancras C. Wong.; Ruth R. Wexler.; Patrick Y. S. Lam. Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa1.J. Med. Chem. 2001, 44 (4), 566-578.

James R. Pruitt.; Donald J. P. Pinto.; Robert A. Galemmo, Jr.; Richard S. Alexander.; Karen A. Rossi.; Brian L. Wells.; Spencer Drummond.; Lori L. Bostrom.; Debra Burdick.; Robert Bruckner.; Haiying Chen.; Angela Smallwood.; Pancras C. Wong.; Matthew R. Wright.; Steven Bai.; Joseph M. Luettgen. ;Robert M. Knabb.; Patrick Y. S. Lam.; Ruth R. Wexler. Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor1. J. Med. Chem. 2003, 46 (25),5298-5315 .

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2933.19
TSCA
No
RTECS
UQ6407500

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