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2-Amino-6-chloropyrazine is used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.
Paul J. J. Colbon; Alison C. Foster; Melvyn E. Giles; Zakariya Patel; and John T. Singleton. A general and efficient route to 6-methyl-pyrazin-2-yl-amines: Alkylation of 2,6-dichloropyrazine via malonate derivatives. Journal of Heterocyclic Chemistry. 2008, 45(5), 1451-1456.
Wisterowicz K; Foks H; Janowiec M; Zwolska-Kwiek Z. Studies on pyrazine derivatives. XXVI. Synthesis and tuberculostatic activity of N-pyrazinylthiourea. Acta Poloniae Pharmaceutica. 1989, 46(2), 101-113.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.