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Methyl 3-oxocyclobutanecarboxylate can be used as an intermediate for the synthesis of various pharmaceutical compounds. It is used for the preparation of novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.
A. Bashir-Hashemi; J. R. Hardee; Nathan Gelber; Lida Qi; Theodore Axenrod. Regioselectivity in Photochemical Chlorocarbonylation of Carbonyl Compounds. J. Org. Chem. 1994, 59(8), 2132-2134.
Christian Stevens and Norbert De Kimpe. A New Entry into 2-Azabicyclo[2.1.1]hexanes via 3-(Chloromethyl)cyclobutanone. J. Org. Chem. 1996, 61(6), 2174-2178.