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Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.
Paul A. Roethle; Ryan M. McFadden; Hong Yang; Paul Hrvatin; Hon Hui; Michael Graupe; Brian Gallagher; Jessica Chao; Joseph Hesselgesser; Paul Duatschek; Jim Zheng; Bing Lu; Daniel B. Tumas; Jason Perry; and Randall L. Halcomb. Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis. J. Med. Chem.2013 56(18), 7324-7333.
Jennifer M. Frost; Michael J. Dart; Karin R. Tietje; Tiffany R. Garrison; George K. Grayson; Anthony V. Daza; Odile F. El-Kouhen; Betty B. Yao; Gin C. Hsieh; Madhavi Pai; Chang Z. Zhu; Prasant Chandran; and Michael D. Meyer. Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity.
Gefahrenhinweise (EU): H227-H315-H318-H335
Combustible liquid. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.