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357-08-4 - Naloxone hydrochloride, 98% - J60013 - Alfa Aesar

J60013 Naloxone hydrochloride, 98%

CAS-Nummer
357-08-4
Synonyme

Größe Preis ($) Menge Verfügbarkeit
100mg 66,20
500mg 220,00
1g 407,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Naloxone hydrochloride, 98%

MDL
MFCD00069322
EINECS
206-611-0

Chemische Eigenschaften

Formel
C19H21NO4•HCl
Molmasse
363.84
Form
Crystalline powder
Schmelzpunkt
200-205°
Löslichkeit
Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml) and dimethyl sulfoxide (73 mg/ml). Insoluble in ether

Anwendungen

A specific opiate antagonist. Blocks the action of sigma-agonists at opioid sites. It is used as an antidote for opioid overdose or for the prevention of overdose. Also used in combination with buprenorphine in the treatment of opiate addiction and in pain management.

Bemerkungen

Refrigerate. Keep container tightly closed. Store away from oxidizing agent.

Literaturverweise

Le Bourdonnec, B., Barker, W.M., Belanger, S. et al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as ? opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett.20086(18), 2006-2012.

Boyer, E.W. Management of opioid analgesic overdose. N Engl J Med.2012367(2), 146-155.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,6362
Harmonized Tariff Code
2939.19
TSCA
No
RTECS
QD2275000

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