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289905-88-0 - TRAM 34 - 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole - J60019 - Alfa Aesar

J60019 TRAM 34

CAS-Nummer
289905-88-0
Synonyme
1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

Größe Preis ($) Menge Verfügbarkeit
25mg 243,00
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TRAM 34

MDL
MFCD09842562

Chemische Eigenschaften

Formel
C22H17ClN2
Molmasse
344.84
Form
Powder
Schmelzpunkt
145-147°
Löslichkeit
Soluble in DMSO at 2mg/ml. Insoluble in water

Anwendungen

TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel. Clotrimazole impurity. Also used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Bemerkungen

Refrigerate. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

H Wulff; M J Miller; W Hansel; S Grissmer; M D Cahalan; K G Chandy. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. PNAS, 97(14), 8151-8156.

K George Chandy; Heike Wulff; Christine Beeton; Michael Pennington; George A Gutman; Michael D Cahalan. K+ channels as targets for specific immunomodulation. Trends in Pharmacological Sciences, 2004, 25(5), 280-289.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302

Harmful if swallowed.

Sicherheitshinweise: P264-P270-P301+P312a-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2933.19
TSCA
No

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