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1684-40-8 - Tacrine hydrochloride - 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride - THA hydrochloride - J60070 - Alfa Aesar

J60070 Tacrine hydrochloride

CAS-Nummer
1684-40-8
Synonyme
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride
THA hydrochloride

Größe Preis ($) Menge Verfügbarkeit
500mg 0,00
5g 167,00
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Tacrine hydrochloride

MDL
MFCD00150067
EINECS
216-867-5

Chemische Eigenschaften

Formel
C13H14N2•HCl
Molmasse
234.73(anhy)
Form
Crystalline solid
Schmelzpunkt
283-284°
Löslichkeit
Soluble in aqueous buffers

Anwendungen

A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.

Bemerkungen

Refrigerate. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literaturverweise

Shuai Qian; Lisi He; Marvin Mak; Yifan Han; Chun-Yu Ho; Zhong Zuo. Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. International Journal of Pharmaceutics, 2014, 477(1-2), 442-453.

Jinggong Liu et. al. Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - General Subjects, 2006,1840(9).

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H331-H315-H319-H335

Harmful if swallowed. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,9024
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2933.99
TSCA
No
RTECS
AR9532500

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