Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

78111-17-8 - Okadaic acid, 98% - J60155 - Alfa Aesar

J60155 Okadaic acid, 98%

CAS-Nummer
78111-17-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
50microgram 94,10
100microg 167,00
300microg 451,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Okadaic acid, 98%

MDL
MFCD00083455

Chemische Eigenschaften

Formel
C44H68O13
Molmasse
805.02
Form
Powder
Löslichkeit
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Anwendungen

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Literaturverweise

Haystead et al. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature .  1989, 337,(6202), 78-81.

Nuydens et al. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998, 70,(3), 1124-33.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H310-H330-H315

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation.

Sicherheitshinweise: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,6819
Gefahrenklasse
6.1
Verpackungsgruppe
I
Harmonized Tariff Code
2932.19
TSCA
No
RTECS
AA8227800

Empfohlen

  • H50451

    4-(4-Chlorophenoxy)benzaldehyde, 98%
  • 13255

    Lead single crystal, 15mm (0.59in) dia, 50mm (2.0in) long, random orientation
  • H64801

    3,5-Dichloro-6-hydroxyaniline, 98+%
  • A10568

    Ethyl p-toluate, 98+%
  • H33894

    3-(4-Fluoro-3-methoxyphenyl)propionic acid, 96%

Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

Katalysatoren

Forschungs- und Laborbedarf