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118409-57-7 - Tyrphostin A23, 99% - Tyrphostin AG-18 - 2-(3,4-Dihydroxybenzylidene)malononitrile - J60308 - Alfa Aesar

J60308 Tyrphostin A23, 99%

CAS-Nummer
118409-57-7
Synonyme
Tyrphostin AG-18
2-(3,4-Dihydroxybenzylidene)malononitrile

Größe Preis ($) Menge Verfügbarkeit
5mg 66,70
10mg 127,00
25mg 301,00
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Tyrphostin A23, 99%

MDL
MFCD00133899

Chemische Eigenschaften

Formel
C10H6N2O2
Molmasse
186.17
Form
Powder
Löslichkeit
Soluble in DMSO, ethanol, or DMF

Anwendungen

Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

Bemerkungen

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.

Literaturverweise

S Dunzendorfer; P Schratzberger; N Reinisch, C M Kähler; C J Wiedermann. Secretoneurin, a novel neuropeptide, is a potent chemoattractant for human eosinophils. Blood.1998, 91 (5), 1527-1532.

A Gazit; P Yaish; C Gilon; A Levitzki. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. Journal of Medicinal Chemistry. 1989, 32, (10), 2344-2352.

Weitere Referenzen

Harmonized Tariff Code
2926.90
TSCA
No

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