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Astemizole, is used as a potent and selective H1-receptor antagonist that displays antihistamine and antimalarial activity. It is also been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.
Cavalli et al. Towards a pharmacophore for drugs inducing the long QT syndrome: Insights from a CoMFA study of hERG K+ channel blockers. . J.Med.Chem.. 2002, 45,(18), 3844-53.
Chong et al. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat.Chem.Biol. 2006, 2,(8), 415-6.
Gefahrenhinweise (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.