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637-07-0 - Clofibrate, 95+% - Ethyl 2-(4-chlorophenoxy)isobutyrate - 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester - J60342 - Alfa Aesar

J60342 Clofibrate, 95+%

CAS-Nummer
637-07-0
Synonyme
Ethyl 2-(4-chlorophenoxy)isobutyrate
2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester

Größe Preis ($) Menge Verfügbarkeit
1g 17,50
5g 20,30
25g 80,50
100g 239,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Clofibrate, 95+%

MDL
MFCD00000615
EINECS
211-277-4

Chemische Eigenschaften

Formel
C12H15ClO3
Molmasse
242.70
Form
Liquid
Siedepunkt
154-156°
Flammpunkt
113°(235°F)
Dichte
1.14
Brechungsindex
1.5
Löslichkeit
Soluble to 100 mM in DMSO.

Anwendungen

It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well. Clofibrate is a ligand agonist for PPARα (peroxisome proliferator-activated receptor α), or an inducer of cytochromes P450’s CYP4A1 and CYP4A3.

Bemerkungen

Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, heat, bases. Store in refrigerator.

Literaturverweise

S Oikawa; H Midorikawa.[Clofibrate treatment of hyperlipoproteinemia]. Nippon rinsho. Japanese journal of clinical medicine.1994, 52 (12), 3285-3291.

W Reuter; A Seifert. [The treatment of essential hyperlipidemia with clofibrate]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. 1969, 24 (1), Suppl-Supp7.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Sicherheitshinweise: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,2377
Beilstein
1913459
Gefahrenklasse
9
Verpackungsgruppe
III
Harmonized Tariff Code
2918.99
TSCA
No
RTECS
UE9480000

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