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117591-20-5 - Calpeptin, 98+% - N-Benzyloxycarbonyl-L-leucyl-norleucinal - Z-Leu-norleucinal - J60481 - Alfa Aesar

J60481 Calpeptin, 98+%

CAS-Nummer
117591-20-5
Synonyme
N-Benzyloxycarbonyl-L-leucyl-norleucinal
Z-Leu-norleucinal

Größe Preis ($) Menge Verfügbarkeit
10mg 188,00
50mg 756,00
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Calpeptin, 98+%

MDL
MFCD00155623

Chemische Eigenschaften

Formel
C20H30N2O4
Molmasse
362.50
Form
Powder
Löslichkeit
Soluble in DMSO at 15mg/ml

Anwendungen

Calpeptin is used to to inhibit the activities of cathepsin L and calpain-1. Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. It acts as an inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. It is shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C Store with desiccant. Keep away fom strong oxidizing agents.

Literaturverweise

Tsujinaka et al. Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem.Biophys.Res.Commun.  1988, 153  ,(3), 1201-8.

Sasaki et al. Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 1990, 3 ,(3), 195-201.

GHS Gefahren- und Sicherheitshinweise

Sicherheitshinweise: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Harmonized Tariff Code
2924.19
TSCA
No

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