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15291-77-7 - Ginkgolide B - BN-52021 - J60646 - Alfa Aesar

J60646 Ginkgolide B

CAS-Nummer
15291-77-7
Synonyme
BN-52021

Größe Preis ($) Menge Verfügbarkeit
10mg 77,80
50mg 268,00
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Ginkgolide B

MDL
MFCD05662347

Chemische Eigenschaften

Formel
C20H24O10
Molmasse
424.40
Form
Powder
Löslichkeit
Soluble in DMSO. Slightly soluble in water and ethanol

Anwendungen

Ginkgolide B is used as a potent PAF-R antagonist. Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally, this compound has been reported to inhibit neutrophil degranulation in vitro. Inhibits superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Literaturverweise

Desquand et al. Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 1986, 127 ,(1-2), 83-95.

Foldes-Filep et al. Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 1987, 148,(3), 1412-7.

Weitere Referenzen

Merck
14,4426
Harmonized Tariff Code
2932.20
TSCA
No

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