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105628-07-7 - Fasudil monohydrochloride, 99+% - HA-1077 hydrochloride - Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride - J60751 - Alfa Aesar

J60751 Fasudil monohydrochloride, 99+%

CAS-Nummer
105628-07-7
Synonyme
HA-1077 hydrochloride
Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride

Größe Preis ($) Menge Verfügbarkeit
250mg 245,00
500mg 366,00
1g 550,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Fasudil monohydrochloride, 99+%

MDL
MFCD00943198

Chemische Eigenschaften

Formel
C14H17N3O2S•HCl
Molmasse
327.83
Form
Powder
Löslichkeit
Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.

Anwendungen

Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration.

Bemerkungen

Incompatible with acids, bases and oxidizing agents.

Literaturverweise

Gupta, N.; Patel, B.; Ahsan, F. Nano-Engineered Erythrocyte Ghosts as Inhalational Carriers for Delivery of Fasudil: Preparation and Characterization. Pharm. Res. 2014, 31 (6), 1553-1565.

Tang, A. T.; Campbell, W. B.; Nithipatikom, K. ROCK1 feedback regulation of the upstream small GTPase RhoA. Cell. Signalling 2012, 24 (7), 1375-1380.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H302

Harmful if swallowed.

Sicherheitshinweise: P264-P270-P301+P312a-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,3942
Harmonized Tariff Code
2935.90
TSCA
No
RTECS
HM4031166

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