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Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized to synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Shi, L.; Liang, L.; Wang, F.; Ma, J.; Sun, J. Polycondensation of guanidine hydrochloride into a graphitic carbon nitride semiconductor with a large surface area as a visible light photocatalyst. Catal. Sci. Tech. 2014, 4 (9), 3235-3243.
Dhondge, S. S.; Shende, P. H.; Paliwal, L. J.; Deshmukh, D. W. Volumetric and acoustic study of aqueous binary mixtures of quinine hydrochloride, guanidine hydrochloride and quinic acid at different temperatures. J. Chem. Thermodyn. 2015, 81, 34-43.
Gefahrenhinweise (EU): H302-H315-H319
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.