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Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
A.D.Caperta; M.Delgado; F.Ressurreicao; A.Meister; R.N.Jones; W.Viegas; A.Houben. Colchicine-induced polyploidization depends on tubulin polymerization in c-metaphase cells. Protoplasma. 2006, 227,(2-4), 147-153.
A.B.Mendes-Bonato; M.Ferrari Felismino; A.M.Souza Kaneshima; C.Pessim; V.Calisto; M.Suely Pagliarini; C.Borges do Valle. Abnormal meiosis in tetraploid genotypes of Brachiaria brizantha (Poaceae) induced by colchicine: its implications for breeding. Journal of Applied Genetics. 2009, 50,(2), 83-87.
Gefahrenhinweise (EU): H300-H340
Fatal if swallowed. May cause genetic defects.
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