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64-86-8 - Colchicine, 98% - J61072 - Alfa Aesar

J61072 Colchicine, 98%

CAS-Nummer
64-86-8
Synonyme

Größe Preis ($) Menge Verfügbarkeit
500mg 46,10
1g 80,70
5g 269,00
Zum Warenkorb hinzufügen Zur Angebotsanfrage hinzufügen Artikel anzeigen

Colchicine, 98%

MDL
MFCD00078484
EINECS
200-598-5

Chemische Eigenschaften

Formel
C22H25NO6
Molmasse
399.44
Form
Powder
Schmelzpunkt
ca 150° dec.
Sensitivität
Light Sensitive
Löslichkeit
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.

Anwendungen

Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Bemerkungen

Light sensitive. Incompatible with oxidizing agents.

Literaturverweise

A.D.Caperta; M.Delgado; F.Ressurreicao; A.Meister; R.N.Jones; W.Viegas; A.Houben. Colchicine-induced polyploidization depends on tubulin polymerization in c-metaphase cells. Protoplasma. 2006, 227,(2-4), 147-153.

 

A.B.Mendes-Bonato; M.Ferrari Felismino; A.M.Souza Kaneshima; C.Pessim; V.Calisto; M.Suely Pagliarini; C.Borges do Valle. Abnormal meiosis in tetraploid genotypes of Brachiaria brizantha (Poaceae) induced by colchicine: its implications for breeding. Journal of Applied Genetics. 2009, 50,(2), 83-87.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H340

Fatal if swallowed. May cause genetic defects.

Sicherheitshinweise: P201-P280-P301+P310a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,2471
Beilstein
2228813
Gefahrenklasse
6.1
Verpackungsgruppe
I
Harmonized Tariff Code
2939.80
TSCA
Yes
RTECS
GH0700000

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