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58970-76-6 - Bestatin - Ubenimex - N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutanoyl]-L-leucine - J61106 - Alfa Aesar

J61106 Bestatin

CAS-Nummer
58970-76-6
Synonyme
Ubenimex
N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutanoyl]-L-leucine

Größe Preis ($) Menge Verfügbarkeit
100mg 76,50
250mg 153,00
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Bestatin

MDL
MFCD00083262
EINECS
261-529-2

Chemische Eigenschaften

Formel
C16H24N2O4
Molmasse
308.37
Form
Powder
Schmelzpunkt
233-236°
Löslichkeit
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.

Anwendungen

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

Umezawa et al. Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J.Antibiot. 1976, 29,(1), 97-9.

Imamura and Kimura. Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N. Leuk.Lymphoma . 2000, 37,(5-6), 663-7.

Weitere Referenzen

Merck
14,9842
Harmonized Tariff Code
2924.29
TSCA
No
RTECS
OH2915000

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