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357-57-3 - Brucine - 10,11-Dimethoxystrychnine - J61178 - Alfa Aesar

J61178 Brucine

CAS-Nummer
357-57-3
Synonyme
10,11-Dimethoxystrychnine

Größe Preis ($) Menge Verfügbarkeit
5g 24,50
25g 64,20
100g 215,00
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Brucine

MDL
MFCD00005942
EINECS
206-614-7

Chemische Eigenschaften

Formel
C23H26N2O4
Molmasse
394.47
Form
Powder
Schmelzpunkt
175-178° dec.
Löslichkeit
Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol

Anwendungen

Brucine is used as a denaturing alcohol, lubricant additive, separation of racemic mixtures. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects.

Bemerkungen

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literaturverweise

Agrawal SS et al. Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line Life Sci. 2011, 89,(5-6), 147-58.

Deng X et al. The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway. Toxicol Sci. 2006, 91,(1), 59-69.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H300-H330

Fatal if swallowed. Fatal if inhaled.

Sicherheitshinweise: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,1455
Beilstein
63046
Gefahrenklasse
6.1
Verpackungsgruppe
I
Harmonized Tariff Code
2939.80
TSCA
Yes
RTECS
EH8925000

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Kürzlich angesehen

Chemikalien

Life science

Metalle und Stoffe

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