I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.
R.R.Tuttle; J.Mills. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circulation Research. 1975, 36,(1), 185-196.
Y.Huang; K.H.Kwok; N.W.Chan; C.W.Lau; Z.Y.Chen. Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery. Clinical and Experimental Pharmacology and Physiology. 1998, 25,(6), 405-411.
Gefahrenhinweise (EU): H302-H312-H332-H361
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Suspected of damaging fertility or the unborn child.
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.