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28643-80-3 - Nigericin sodium salt, 98+% - Antibiotic K178 sodium salt - J61349 - Alfa Aesar

J61349 Nigericin sodium salt, 98+%

CAS-Nummer
28643-80-3
Synonyme
Antibiotic K178 sodium salt

Größe Preis ($) Menge Verfügbarkeit
10mg 133,00
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Nigericin sodium salt, 98+%

MDL
MFCD00036825

Chemische Eigenschaften

Formel
C40H67NaO11
Molmasse
746.94
Form
Powder
Löslichkeit
Soluble in chloroform, methanol or ethanol

Anwendungen

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

Bemerkungen

Stable under recommended storage conditions. Incompatible with oxidizing agents, acids, bases and heat.

Literaturverweise

K.Suzuki; K.Tohda; H.Aruga; M.Matsuzoe; H.Inoue; T.Shirai. Ion-selective electrodes based on natural carboxylic polyether antibiotics. Analytical chemistry. 1988, 60,(17), 1714-1721.

 

Benjamin Rey; Damien Roussel; Caroline Romestaing; Maud Belouze; Jean-Louis Rouanet; Dominique Desplanches; Brigitte Sibille; Stephane Servais; Claude Duchamp. Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria. BMC Physiology. 2010, 10,5.

GHS Gefahren- und Sicherheitshinweise

Gefahrenhinweise (EU): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Sicherheitshinweise: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Weitere Referenzen

Merck
14,6541
Beilstein
3892398
Gefahrenklasse
6.1
Verpackungsgruppe
III
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
QT6840000

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